Drug interactions
Fostemsavir + Rosuvastatin
Severity: Moderate
Fostemsavir and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostemsavir's active moiety inhibits OATP1B1/3 and BCRP, and rosuvastatin exposure may rise. The risk of myopathy is therefore increased, particularly at high doses.
What this interaction means in plain words
Fostemsavir and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fostemsavir belongs to Anti Virals; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1/3 and BCRP transporters increases rosuvastatin plasma concentrations.
What to do
Use the lowest effective rosuvastatin dose and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Fostemsavir
- Apalutamide + Fostemsavir Contraindicated
- Carbamazepine + Fostemsavir Contraindicated
- Enzalutamide + Fostemsavir Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Fostemsavir + Phenytoin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Fostemsavir with Rosuvastatin?
MediHelp rates the interaction as moderate. Fostemsavir and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostemsavir's active moiety inhibits OATP1B1/3 and BCRP, and rosuvastatin exposure may rise. The risk of myopathy is therefore increased, particularly at high doses.
How serious is the interaction between Fostemsavir and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective rosuvastatin dose and monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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