Drug interactions
Frovatriptan + Granisetron
Severity: Moderate
Frovatriptan and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs act on serotonin receptors, and serotonin syndrome has been described with 5-HT3 antagonists and triptans. The risk is low, and triptans are used only intermittently.
What this interaction means in plain words
Frovatriptan and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Theoretical additive serotonergic activity; the mechanism is not firmly established.
What to do
Counsel the patient to report agitation, tremor, sweating or fever after dosing. Stop both agents and give supportive care if serotonin syndrome occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Granisetron?
MediHelp rates the interaction as moderate. Frovatriptan and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs act on serotonin receptors, and serotonin syndrome has been described with 5-HT3 antagonists and triptans. The risk is low, and triptans are used only intermittently.
How serious is the interaction between Frovatriptan and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating or fever after dosing. Stop both agents and give supportive care if serotonin syndrome occurs.
What other medicines interact with Granisetron?
MediHelp also lists interactions of Granisetron with, for example, Apomorphine, Amiodarone, Amisulpride. The full list is on the Granisetron page.
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