Drug interactions
Frovatriptan + Iloperidone
Severity: Moderate
Frovatriptan and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone is an atypical antipsychotic with serotonin 5-HT2A and dopamine D2 antagonism. Combined with a triptan, serotonin toxicity or neuroleptic malignant syndrome is theoretically possible, though rarely reported.
What this interaction means in plain words
Frovatriptan and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Iloperidone belongs to Central Nervous System.
Why it happens
Overlapping serotonergic modulation with dopamine D2 blockade; theoretical.
What to do
Monitor for mental status change, hyperthermia, rigidity and autonomic instability. Stop the drugs and treat if either syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Frovatriptan with Iloperidone?
MediHelp rates the interaction as moderate. Frovatriptan and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone is an atypical antipsychotic with serotonin 5-HT2A and dopamine D2 antagonism. Combined with a triptan, serotonin toxicity or neuroleptic malignant syndrome is theoretically possible, though rarely reported.
How serious is the interaction between Frovatriptan and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity and autonomic instability. Stop the drugs and treat if either syndrome is suspected.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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