Drug interactions
Frovatriptan + Levomilnacipran
Severity: Moderate
Frovatriptan and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran, a serotonin-norepinephrine reuptake inhibitor, combined with a triptan may lead to serotonin syndrome. Cases are rare but the outcome can be serious.
What this interaction means in plain words
Frovatriptan and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Frovatriptan belongs to Central Nervous System; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive serotonergic effects from SNRI reuptake inhibition and triptan 5-HT1B/1D receptor agonism.
What to do
Monitor for agitation, tremor, hyperthermia and autonomic instability, particularly at initiation or dose increases. Discontinue one or both agents if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Frovatriptan with Levomilnacipran?
MediHelp rates the interaction as moderate. Frovatriptan and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran, a serotonin-norepinephrine reuptake inhibitor, combined with a triptan may lead to serotonin syndrome. Cases are rare but the outcome can be serious.
How serious is the interaction between Frovatriptan and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia and autonomic instability, particularly at initiation or dose increases. Discontinue one or both agents if serotonin syndrome is suspected.
What other medicines interact with Frovatriptan?
MediHelp also lists interactions of Frovatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Frovatriptan page.
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