Drug interactions
Frovatriptan + Lurasidone
Severity: Minor
Frovatriptan and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Frovatriptan is a 5-HT1B/1D agonist and lurasidone has serotonergic receptor activity, so additive serotonergic effects are theoretically possible. Clinical reports of serotonin syndrome with this pair are scarce.
What this interaction means in plain words
Frovatriptan and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Frovatriptan belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic effects; no established pharmacokinetic interaction.
What to do
No dose adjustment is required. Counsel the patient to report agitation, tremor, fever or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Lurasidone?
MediHelp rates the interaction as minor. Frovatriptan and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Frovatriptan is a 5-HT1B/1D agonist and lurasidone has serotonergic receptor activity, so additive serotonergic effects are theoretically possible. Clinical reports of serotonin syndrome with this pair are scarce.
How serious is the interaction between Frovatriptan and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Counsel the patient to report agitation, tremor, fever or diarrhea.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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