Drug interactions
Frovatriptan + Pentazocine
Severity: Minor
Frovatriptan and Pentazocine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a triptan with an opioid that has weak serotonergic activity could theoretically contribute to serotonin syndrome. Pentazocine is not a strong serotonergic opioid, so the risk is likely small and based mostly on extrapolation.
What this interaction means in plain words
Frovatriptan and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Frovatriptan belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic effects; pentazocine's serotonergic activity is not well established.
What to do
No routine change is needed. Advise patients to report agitation, tremor, sweating, diarrhea or fever, and assess for serotonin syndrome if these occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Frovatriptan with Pentazocine?
MediHelp rates the interaction as minor. Frovatriptan and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Concurrent use of a triptan with an opioid that has weak serotonergic activity could theoretically contribute to serotonin syndrome. Pentazocine is not a strong serotonergic opioid, so the risk is likely small and based mostly on extrapolation.
How serious is the interaction between Frovatriptan and Pentazocine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients to report agitation, tremor, sweating, diarrhea or fever, and assess for serotonin syndrome if these occur.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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