Drug interactions
Fruquintinib + Secobarbital
Severity: Moderate
Fruquintinib and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital may lower fruquintinib concentrations through CYP3A4 induction, potentially reducing anticancer efficacy. Labeling suggests moderate inducers do not require dose change, but secobarbital's effect is of uncertain magnitude.
What this interaction means in plain words
Fruquintinib and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fruquintinib belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases fruquintinib metabolism.
What to do
Prefer a non-inducing sedative; if the combination is required, continue the standard fruquintinib dose and monitor tumor response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Fruquintinib
- Amobarbital + Fruquintinib Major
- Apalutamide + Fruquintinib Major
- Carbamazepine + Fruquintinib Major
- Enzalutamide + Fruquintinib Major
- Fruquintinib + Phenytoin Major
- Bosentan + Fruquintinib Moderate
Frequently asked questions
Can I take Fruquintinib with Secobarbital?
MediHelp rates the interaction as moderate. Fruquintinib and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital may lower fruquintinib concentrations through CYP3A4 induction, potentially reducing anticancer efficacy. Labeling suggests moderate inducers do not require dose change, but secobarbital's effect is of uncertain magnitude.
How serious is the interaction between Fruquintinib and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing sedative; if the combination is required, continue the standard fruquintinib dose and monitor tumor response and tolerability.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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