Drug interactions
Fruquintinib + Warfarin
Severity: Moderate
Fruquintinib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fruquintinib, a VEGFR inhibitor, can cause serious hemorrhagic events. Combining it with warfarin may add to bleeding risk.
What this interaction means in plain words
Fruquintinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fruquintinib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic bleeding risk from VEGFR inhibition together with anticoagulation.
What to do
Monitor INR and for signs of bleeding regularly, and adjust warfarin as needed. Interrupt fruquintinib for serious bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Fruquintinib
- Amobarbital + Fruquintinib Major
- Apalutamide + Fruquintinib Major
- Carbamazepine + Fruquintinib Major
- Enzalutamide + Fruquintinib Major
- Fruquintinib + Phenytoin Major
- Bosentan + Fruquintinib Moderate
Frequently asked questions
Can I take Fruquintinib with Warfarin?
MediHelp rates the interaction as moderate. Fruquintinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fruquintinib, a VEGFR inhibitor, can cause serious hemorrhagic events. Combining it with warfarin may add to bleeding risk.
How serious is the interaction between Fruquintinib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and for signs of bleeding regularly, and adjust warfarin as needed. Interrupt fruquintinib for serious bleeding.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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