Drug interactions
Furosemide + Glipizide-metformin
Severity: Moderate
Furosemide and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can raise metformin concentrations, and loop diuretics may worsen glycemic control. Volume depletion or reduced renal function from diuresis could further increase metformin exposure and the lactic acidosis risk.
What this interaction means in plain words
Furosemide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Furosemide may reduce renal clearance of metformin and can cause hyperglycemia through potassium depletion and impaired insulin secretion.
What to do
Monitor blood glucose and renal function, and adjust antidiabetic doses if control changes; ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Glipizide-metformin?
MediHelp rates the interaction as moderate. Furosemide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can raise metformin concentrations, and loop diuretics may worsen glycemic control. Volume depletion or reduced renal function from diuresis could further increase metformin exposure and the lactic acidosis risk.
How serious is the interaction between Furosemide and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and adjust antidiabetic doses if control changes; ensure adequate hydration.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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