Drug interactions
Furosemide + Glyburide-metformin
Severity: Moderate
Furosemide and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can modestly raise metformin exposure, and loop diuretics may also impair glycemic control or cause volume depletion that affects renal function. In susceptible patients this could reduce glucose control or increase the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Furosemide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Furosemide may raise metformin plasma concentrations (possibly via renal transport competition), while diuretic-induced volume depletion and renal impairment further reduce metformin clearance.
What to do
Monitor blood glucose and renal function when furosemide is started, stopped or changed. Adjust the antidiabetic dose if glucose control shifts and reassess metformin if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Glyburide-metformin?
MediHelp rates the interaction as moderate. Furosemide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can modestly raise metformin exposure, and loop diuretics may also impair glycemic control or cause volume depletion that affects renal function. In susceptible patients this could reduce glucose control or increase the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Furosemide and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when furosemide is started, stopped or changed. Adjust the antidiabetic dose if glucose control shifts and reassess metformin if renal function declines.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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