Drug interactions
Furosemide + Hydrochlorothiazide-telmisartan
Severity: Moderate
Furosemide and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide combined with a thiazide gives a strong sequential diuretic effect, which can cause excessive fluid and electrolyte loss. With telmisartan on board, volume depletion can cause hypotension and acute renal impairment, although telmisartan partly offsets potassium loss.
What this interaction means in plain words
Furosemide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Loop and thiazide diuretics block sodium reabsorption at different nephron sites, and the ARB reduces glomerular filtration pressure when volume is depleted.
What to do
Monitor blood pressure, weight, sodium, potassium and creatinine, especially after initiation or dose changes. Reduce the diuretic dose if hypotension or electrolyte disturbance develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Furosemide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide combined with a thiazide gives a strong sequential diuretic effect, which can cause excessive fluid and electrolyte loss. With telmisartan on board, volume depletion can cause hypotension and acute renal impairment, although telmisartan partly offsets potassium loss.
How serious is the interaction between Furosemide and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, sodium, potassium and creatinine, especially after initiation or dose changes. Reduce the diuretic dose if hypotension or electrolyte disturbance develops.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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