Drug interactions
Furosemide + Hydrochlorothiazide-valsartan
Severity: Moderate
Furosemide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding a loop diuretic to a thiazide and angiotensin receptor blocker combination intensifies diuresis and can cause volume depletion, hypotension, electrolyte disturbance and a decline in renal function. The potassium effect is variable because the valsartan component tends to retain potassium while the two diuretics waste it.
What this interaction means in plain words
Furosemide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects: sequential nephron blockade by two diuretics increases sodium, water, potassium and magnesium loss, while angiotensin receptor blockade reduces renal perfusion pressure and aldosterone-mediated potassium excretion.
What to do
Monitor blood pressure, serum potassium, sodium, magnesium and creatinine after starting or changing doses. Adjust diuretic doses if volume depletion or electrolyte abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Hydrochlorothiazide-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Furosemide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding a loop diuretic to a thiazide and angiotensin receptor blocker combination intensifies diuresis and can cause volume depletion, hypotension, electrolyte disturbance and a decline in renal function. The potassium effect is variable because the valsartan component tends to retain potassium while the two diuretics waste it.
How serious is the interaction between Furosemide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium, sodium, magnesium and creatinine after starting or changing doses. Adjust diuretic doses if volume depletion or electrolyte abnormalities develop.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
