Drug interactions
Furosemide + Insulin degludec
Severity: Moderate
Furosemide and Insulin degludec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics can impair glucose tolerance, partly through hypokalemia, and may reduce the glucose-lowering effect of insulin. This may lead to higher glucose levels and a need for insulin dose adjustment.
What this interaction means in plain words
Furosemide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Insulin degludec belongs to Endocrine.
Why it happens
Diuretic-induced hypokalemia reduces insulin secretion and sensitivity, opposing insulin's glucose-lowering effect.
What to do
Monitor blood glucose and serum potassium when starting or changing furosemide. Adjust insulin degludec dose as needed and correct hypokalemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Insulin degludec
Frequently asked questions
Can I take Furosemide with Insulin degludec?
MediHelp rates the interaction as moderate. Furosemide and Insulin degludec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics can impair glucose tolerance, partly through hypokalemia, and may reduce the glucose-lowering effect of insulin. This may lead to higher glucose levels and a need for insulin dose adjustment.
How serious is the interaction between Furosemide and Insulin degludec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium when starting or changing furosemide. Adjust insulin degludec dose as needed and correct hypokalemia.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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