Drug interactions
furosemide + lisinopril
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive blood pressure lowering; first‑dose hypotension may occur in volume‑depleted patients; risk of acute kidney injury with aggressive diuresis.
Mechanism of action
ACE inhibitor vasodilation combined with diuretic‑induced volume depletion lowers perfusion pressure and GFR.
Clinical management
Assess volume status; consider reducing or withholding diuretic 24 h before starting or up‑titrating ACE inhibitor; monitor BP, serum creatinine, and electrolytes 1–2 weeks after changes.
Drug reference
References
- Lisinopril Prescribing Information — FDA Label
- ACE inhibitors and Diuretics: First-dose hypotension — UpToDate
Frequently asked questions
Can I take furosemide with lisinopril?
The interaction is rated: Moderate. Additive blood pressure lowering; first‑dose hypotension may occur in volume‑depleted patients; risk of acute kidney injury with aggressive diuresis.
How serious is the interaction between furosemide and lisinopril?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between furosemide and lisinopril managed?
Assess volume status; consider reducing or withholding diuretic 24 h before starting or up‑titrating ACE inhibitor; monitor BP, serum creatinine, and electrolytes 1–2 weeks after changes.
Why do furosemide and lisinopril interact?
ACE inhibitor vasodilation combined with diuretic‑induced volume depletion lowers perfusion pressure and GFR.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.