Drug interactions
Furosemide + Lofexidine
Severity: Moderate
Furosemide and Lofexidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofexidine lowers blood pressure and heart rate, and furosemide adds blood pressure reduction through volume depletion. Together they can cause marked hypotension, dizziness and syncope. Furosemide-induced hypokalemia or hypomagnesemia may also add to lofexidine's QT risk.
What this interaction means in plain words
Furosemide and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Lofexidine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects of central alpha-2 agonism and loop diuretic volume depletion, with electrolyte loss adding to QT risk.
What to do
Monitor blood pressure, pulse and electrolytes, especially during dose changes. Reduce the dose of either drug if symptomatic hypotension or bradycardia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Lofexidine
- Adagrasib + Lofexidine Major
- Alfuzosin + Lofexidine Major
- Amiodarone + Lofexidine Major
- Amisulpride + Lofexidine Major
- Anagrelide + Lofexidine Major
- Apomorphine + Lofexidine Major
Frequently asked questions
Can I take Furosemide with Lofexidine?
MediHelp rates the interaction as moderate. Furosemide and Lofexidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofexidine lowers blood pressure and heart rate, and furosemide adds blood pressure reduction through volume depletion. Together they can cause marked hypotension, dizziness and syncope. Furosemide-induced hypokalemia or hypomagnesemia may also add to lofexidine's QT risk.
How serious is the interaction between Furosemide and Lofexidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, pulse and electrolytes, especially during dose changes. Reduce the dose of either drug if symptomatic hypotension or bradycardia develops.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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