Drug interactions
Furosemide + Metformin-pioglitazone
Severity: Moderate
Furosemide and Metformin-pioglitazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide may raise metformin concentrations, while metformin may lower furosemide levels. Loop diuretics can also impair glucose tolerance, and volume depletion or renal impairment increases the risk of metformin accumulation. Pioglitazone-related fluid retention may be offset by the diuretic.
What this interaction means in plain words
Furosemide and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Altered renal handling and protein binding may change metformin and furosemide levels, and loop diuretic hyperglycemic effects add pharmacodynamic opposition.
What to do
Monitor blood glucose and renal function, and reassess antidiabetic dosing if furosemide is started or stopped; watch for volume depletion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-pioglitazone
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Metformin-pioglitazone?
MediHelp rates the interaction as moderate. Furosemide and Metformin-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide may raise metformin concentrations, while metformin may lower furosemide levels. Loop diuretics can also impair glucose tolerance, and volume depletion or renal impairment increases the risk of metformin accumulation. Pioglitazone-related fluid retention may be offset by the diuretic.
How serious is the interaction between Furosemide and Metformin-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and reassess antidiabetic dosing if furosemide is started or stopped; watch for volume depletion.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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