Drug interactions
Furosemide + Metformin-repaglinide
Severity: Moderate
Furosemide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide can raise metformin plasma concentrations, while metformin may slightly lower furosemide levels. Volume depletion and renal impairment from diuretic therapy may further increase the risk of metformin accumulation and lactic acidosis.
What this interaction means in plain words
Furosemide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Altered renal handling and protein binding, plus diuretic-related volume depletion, can reduce metformin clearance.
What to do
Monitor renal function, hydration status and glycemic control, and reassess the metformin dose if renal function declines. Review glucose control when furosemide is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Metformin-repaglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metformin-repaglinide
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Furosemide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide can raise metformin plasma concentrations, while metformin may slightly lower furosemide levels. Volume depletion and renal impairment from diuretic therapy may further increase the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Furosemide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, hydration status and glycemic control, and reassess the metformin dose if renal function declines. Review glucose control when furosemide is stopped.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
