Drug interactions
Furosemide + Moexipril
Severity: Moderate
Furosemide and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to a loop diuretic, especially in volume-depleted patients, can cause marked first-dose hypotension and a decline in renal function. The risk is greatest at initiation or after a dose increase, or with sodium depletion or renal artery stenosis.
What this interaction means in plain words
Furosemide and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Moexipril belongs to Cardiovascular.
Why it happens
Volume depletion from diuresis combined with ACE inhibition reduces angiotensin II-mediated efferent arteriolar tone, causing additive hypotension and reduced glomerular filtration.
What to do
Consider temporarily reducing or holding furosemide before starting moexipril, and start with a low dose. Monitor blood pressure, serum creatinine and potassium within the first one to two weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Moexipril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Furosemide with Moexipril?
MediHelp rates the interaction as moderate. Furosemide and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to a loop diuretic, especially in volume-depleted patients, can cause marked first-dose hypotension and a decline in renal function. The risk is greatest at initiation or after a dose increase, or with sodium depletion or renal artery stenosis.
How serious is the interaction between Furosemide and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider temporarily reducing or holding furosemide before starting moexipril, and start with a low dose. Monitor blood pressure, serum creatinine and potassium within the first one to two weeks.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
