Drug interactions
Furosemide + Naproxen
Severity: Moderate
Furosemide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can reduce the diuretic and antihypertensive effects of furosemide and may cause sodium retention. In volume-depleted or susceptible patients the combination raises the risk of acute kidney injury.
What this interaction means in plain words
Furosemide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Naproxen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit renal prostaglandins that support renal blood flow and loop diuretic action, reducing natriuresis and impairing renal perfusion.
What to do
Monitor diuretic response, weight, blood pressure and renal function, and increase furosemide dose if needed. Avoid in dehydrated patients or those with heart failure or renal disease where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Naproxen?
MediHelp rates the interaction as moderate. Furosemide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can reduce the diuretic and antihypertensive effects of furosemide and may cause sodium retention. In volume-depleted or susceptible patients the combination raises the risk of acute kidney injury.
How serious is the interaction between Furosemide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure and renal function, and increase furosemide dose if needed. Avoid in dehydrated patients or those with heart failure or renal disease where possible.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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