Drug interactions
Furosemide + Sacubitril-valsartan
Severity: Moderate
Furosemide and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide promotes potassium loss and volume depletion, whereas sacubitril-valsartan tends to raise potassium and can reduce renal perfusion pressure. Together the net potassium effect is unpredictable, and excessive diuresis may cause hypotension or worsening renal function when combined with the angiotensin receptor blockade.
What this interaction means in plain words
Furosemide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Sacubitril-valsartan belongs to Cardiovascular.
Why it happens
Opposing effects on potassium handling (loop diuretic kaliuresis versus RAAS inhibition) plus additive blood pressure lowering and volume depletion.
What to do
Monitor serum potassium, creatinine, blood pressure and volume status after starting or adjusting either drug. Reduce the diuretic dose if hypotension or volume depletion develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Furosemide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide promotes potassium loss and volume depletion, whereas sacubitril-valsartan tends to raise potassium and can reduce renal perfusion pressure. Together the net potassium effect is unpredictable, and excessive diuresis may cause hypotension or worsening renal function when combined with the angiotensin receptor blockade.
How serious is the interaction between Furosemide and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, creatinine, blood pressure and volume status after starting or adjusting either drug. Reduce the diuretic dose if hypotension or volume depletion develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
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