Drug interactions
Furosemide + Streptomycin
Severity: Major
Furosemide and Streptomycin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide given with aminoglycosides increases the risk of hearing and vestibular damage, which may be irreversible. Volume depletion from the diuretic can also worsen aminoglycoside kidney toxicity.
What this interaction means in plain words
Furosemide and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Furosemide belongs to Cardiovascular; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive ototoxicity and nephrotoxicity, with diuresis-related volume depletion increasing aminoglycoside exposure.
What to do
Avoid the combination if possible, or use the lowest effective doses with adequate hydration. Monitor renal function, aminoglycoside levels and auditory or vestibular symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Furosemide and Streptomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Streptomycin
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Streptomycin?
MediHelp rates the interaction as major. Furosemide and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Furosemide given with aminoglycosides increases the risk of hearing and vestibular damage, which may be irreversible. Volume depletion from the diuretic can also worsen aminoglycoside kidney toxicity.
How serious is the interaction between Furosemide and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible, or use the lowest effective doses with adequate hydration. Monitor renal function, aminoglycoside levels and auditory or vestibular symptoms.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
