Drug interactions
Furosemide + Tadalafil
Severity: Moderate
Furosemide and Tadalafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tadalafil's vasodilation can add to the volume-related blood pressure reduction from furosemide. Volume-depleted patients are at higher risk of dizziness and hypotension.
What this interaction means in plain words
Furosemide and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Tadalafil belongs to Genitourinary.
Why it happens
Additive hypotensive effects of vasodilation and diuretic-induced volume depletion.
What to do
Check blood pressure and hydration status when starting tadalafil. Counsel patients to rise slowly and report lightheadedness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Furosemide with Tadalafil?
MediHelp rates the interaction as moderate. Furosemide and Tadalafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tadalafil's vasodilation can add to the volume-related blood pressure reduction from furosemide. Volume-depleted patients are at higher risk of dizziness and hypotension.
How serious is the interaction between Furosemide and Tadalafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure and hydration status when starting tadalafil. Counsel patients to rise slowly and report lightheadedness.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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