Drug interactions
Furosemide + Trandolapril
Severity: Moderate
Furosemide and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Adding an ACE inhibitor to a loop diuretic can cause marked hypotension and acute renal function decline, particularly at initiation or in volume-depleted patients. The combination is common in heart failure but needs careful start-up.
What this interaction means in plain words
Furosemide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Trandolapril belongs to Cardiovascular.
Why it happens
Diuretic volume depletion plus ACE inhibition lowers efferent arteriolar tone, causing additive hypotension and reduced glomerular filtration.
What to do
Consider reducing or briefly holding furosemide before starting trandolapril, starting at a low dose. Monitor blood pressure, creatinine and potassium in the first one to two weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Furosemide with Trandolapril?
MediHelp rates the interaction as moderate. Furosemide and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Adding an ACE inhibitor to a loop diuretic can cause marked hypotension and acute renal function decline, particularly at initiation or in volume-depleted patients. The combination is common in heart failure but needs careful start-up.
How serious is the interaction between Furosemide and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or briefly holding furosemide before starting trandolapril, starting at a low dose. Monitor blood pressure, creatinine and potassium in the first one to two weeks.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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