Drug interactions
Furosemide + Triamterene
Severity: Moderate
Furosemide and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide causes potassium loss while triamterene retains it, and the two are sometimes combined for this reason. Potassium can still become too high, especially in renal impairment, or too low with excessive loop diuresis.
What this interaction means in plain words
Furosemide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Triamterene belongs to Cardiovascular.
Why it happens
Opposing effects on renal potassium handling: loop diuretic kaliuresis versus triamterene ENaC blockade in the collecting duct.
What to do
Monitor serum potassium and renal function regularly, especially after dose changes. Avoid potassium supplements unless hypokalemia is documented.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Furosemide with Triamterene?
MediHelp rates the interaction as moderate. Furosemide and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide causes potassium loss while triamterene retains it, and the two are sometimes combined for this reason. Potassium can still become too high, especially in renal impairment, or too low with excessive loop diuresis.
How serious is the interaction between Furosemide and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function regularly, especially after dose changes. Avoid potassium supplements unless hypokalemia is documented.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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