Drug interactions
Furosemide + Valsartan
Severity: Moderate
Furosemide and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Furosemide and valsartan together lower blood pressure additively and can cause hypotension or reduced renal function in volume-depleted patients. Valsartan reduces furosemide potassium loss, although hyperkalemia is possible in renal impairment.
What this interaction means in plain words
Furosemide and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Furosemide belongs to Cardiovascular; Valsartan belongs to Cardiovascular.
Why it happens
Volume depletion plus angiotensin receptor blockade gives additive hypotension and reduced glomerular filtration; ARB lowers aldosterone-mediated potassium excretion.
What to do
Monitor blood pressure, creatinine and potassium after starting or changing doses. Consider lowering the diuretic dose if the patient is volume depleted.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Furosemide with Valsartan?
MediHelp rates the interaction as moderate. Furosemide and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Furosemide and valsartan together lower blood pressure additively and can cause hypotension or reduced renal function in volume-depleted patients. Valsartan reduces furosemide potassium loss, although hyperkalemia is possible in renal impairment.
How serious is the interaction between Furosemide and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium after starting or changing doses. Consider lowering the diuretic dose if the patient is volume depleted.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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