Drug interactions
Gabapentin + Mirtazapine
Severity: Moderate
Gabapentin and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and dizziness, so together they can produce excessive drowsiness and psychomotor impairment. Respiratory depression is a concern mainly in elderly patients, those with lung disease, or when other CNS depressants are present.
What this interaction means in plain words
Gabapentin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and titrate gradually, monitoring for sedation and respiratory depression. Take particular care in elderly patients and those with COPD or on opioids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Mirtazapine?
MediHelp rates the interaction as moderate. Gabapentin and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and dizziness, so together they can produce excessive drowsiness and psychomotor impairment. Respiratory depression is a concern mainly in elderly patients, those with lung disease, or when other CNS depressants are present.
How serious is the interaction between Gabapentin and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate gradually, monitoring for sedation and respiratory depression. Take particular care in elderly patients and those with COPD or on opioids.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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