Drug interactions
Gabapentin + Trazodone
Severity: Moderate
Gabapentin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and dizziness, so combining them can lead to excessive drowsiness and impaired psychomotor function. Respiratory depression is a concern mainly in elderly or respiratory-compromised patients or with other CNS depressants.
What this interaction means in plain words
Gabapentin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and titrate gradually, monitoring for sedation and respiratory depression. Give extra care to elderly patients and those with COPD or on opioids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Trazodone?
MediHelp rates the interaction as moderate. Gabapentin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and dizziness, so combining them can lead to excessive drowsiness and impaired psychomotor function. Respiratory depression is a concern mainly in elderly or respiratory-compromised patients or with other CNS depressants.
How serious is the interaction between Gabapentin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate gradually, monitoring for sedation and respiratory depression. Give extra care to elderly patients and those with COPD or on opioids.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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