Drug interactions
Gabapentin enacarbil + Maprotiline
Severity: Moderate
Gabapentin enacarbil and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, and together they can increase sedation, dizziness and impaired psychomotor function. Respiratory depression is a concern with gabapentinoids combined with other CNS depressants, especially in older adults or those with lung disease.
What this interaction means in plain words
Gabapentin enacarbil and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Maprotiline belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Take extra care in patients with respiratory compromise or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Maprotiline?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, and together they can increase sedation, dizziness and impaired psychomotor function. Respiratory depression is a concern with gabapentinoids combined with other CNS depressants, especially in older adults or those with lung disease.
How serious is the interaction between Gabapentin enacarbil and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Take extra care in patients with respiratory compromise or renal impairment.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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