Drug interactions
Gabapentin enacarbil + Milnacipran
Severity: Minor
Gabapentin enacarbil and Milnacipran: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil is converted to gabapentin, which causes sedation and dizziness, and milnacipran can cause dizziness and somnolence. Additive CNS effects may occur, and respiratory depression is a concern mainly in patients with other risk factors.
What this interaction means in plain words
Gabapentin enacarbil and Milnacipran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin enacarbil belongs to Central Nervous System; Milnacipran belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Start with low doses and counsel patients about drowsiness and driving. Monitor sedation, especially in older adults or those on other CNS depressants.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Milnacipran
- Isocarboxazid + Milnacipran Contraindicated
- Methylene blue + Milnacipran Contraindicated
- Milnacipran + Phenelzine Contraindicated
- Milnacipran + Procarbazine Contraindicated
- Milnacipran + Rasagiline Contraindicated
- Milnacipran + Safinamide Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Milnacipran?
MediHelp rates the interaction as minor. Gabapentin enacarbil and Milnacipran have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gabapentin enacarbil is converted to gabapentin, which causes sedation and dizziness, and milnacipran can cause dizziness and somnolence. Additive CNS effects may occur, and respiratory depression is a concern mainly in patients with other risk factors.
How serious is the interaction between Gabapentin enacarbil and Milnacipran?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with low doses and counsel patients about drowsiness and driving. Monitor sedation, especially in older adults or those on other CNS depressants.
What other medicines interact with Milnacipran?
MediHelp also lists interactions of Milnacipran with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Milnacipran page.
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