Drug interactions
Gabapentin enacarbil + Oxymorphone
Severity: Major
Gabapentin enacarbil and Oxymorphone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentinoids combined with opioids increase the risk of profound sedation and respiratory depression, which can be fatal. Risk is greater in older adults, those with lung disease, and with higher doses.
What this interaction means in plain words
Gabapentin enacarbil and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gabapentin enacarbil belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from gabapentinoid and opioid effects.
What to do
Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Consider dose reduction of one or both drugs, especially in elderly or respiratory-compromised patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Oxymorphone?
MediHelp rates the interaction as major. Gabapentin enacarbil and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gabapentinoids combined with opioids increase the risk of profound sedation and respiratory depression, which can be fatal. Risk is greater in older adults, those with lung disease, and with higher doses.
How serious is the interaction between Gabapentin enacarbil and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and monitor for sedation and respiratory depression. Consider dose reduction of one or both drugs, especially in elderly or respiratory-compromised patients.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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