Drug interactions
Gabapentin enacarbil + Ramelteon
Severity: Moderate
Gabapentin enacarbil and Ramelteon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil causes somnolence and dizziness, and ramelteon adds sedative effect. Combined use may increase drowsiness and impair daytime performance.
What this interaction means in plain words
Gabapentin enacarbil and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gabapentin enacarbil belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Use the lowest effective doses and monitor for excessive sedation. Counsel the patient about driving and other hazardous tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Ramelteon?
MediHelp rates the interaction as moderate. Gabapentin enacarbil and Ramelteon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin enacarbil causes somnolence and dizziness, and ramelteon adds sedative effect. Combined use may increase drowsiness and impair daytime performance.
How serious is the interaction between Gabapentin enacarbil and Ramelteon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excessive sedation. Counsel the patient about driving and other hazardous tasks.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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