Drug interactions
Gabapentin enacarbil + Sertraline
Severity: Minor
Gabapentin enacarbil and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin enacarbil is converted to gabapentin, which can cause sedation and dizziness, and sertraline can also cause somnolence in some patients. Additive CNS effects are possible, though serious respiratory depression is mainly a concern when opioids or other strong depressants are involved.
What this interaction means in plain words
Gabapentin enacarbil and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gabapentin enacarbil belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective gabapentin enacarbil dose and warn about drowsiness and impaired driving. Monitor for excess sedation, particularly in older or respiratory-compromised patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Gabapentin enacarbil
Frequently asked questions
Can I take Gabapentin enacarbil with Sertraline?
MediHelp rates the interaction as minor. Gabapentin enacarbil and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gabapentin enacarbil is converted to gabapentin, which can cause sedation and dizziness, and sertraline can also cause somnolence in some patients. Additive CNS effects are possible, though serious respiratory depression is mainly a concern when opioids or other strong depressants are involved.
How serious is the interaction between Gabapentin enacarbil and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective gabapentin enacarbil dose and warn about drowsiness and impaired driving. Monitor for excess sedation, particularly in older or respiratory-compromised patients.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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