Drug interactions
Gadobenate + Sotalol
Severity: Moderate
Gadobenate and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gadobenate is a gadolinium contrast agent that has been linked in labeling to minor QT prolongation, so theoretical additive risk exists with sotalol. The clinical significance with a single contrast dose is uncertain but may matter in patients with other arrhythmia risk factors.
What this interaction means in plain words
Gadobenate and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation; the mechanism for gadobenate is not well established.
What to do
Check baseline QTc and electrolytes in patients with additional risk factors, and consider ECG monitoring after contrast administration. No routine interruption of sotalol is usually needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Gadobenate with Sotalol?
MediHelp rates the interaction as moderate. Gadobenate and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gadobenate is a gadolinium contrast agent that has been linked in labeling to minor QT prolongation, so theoretical additive risk exists with sotalol. The clinical significance with a single contrast dose is uncertain but may matter in patients with other arrhythmia risk factors.
How serious is the interaction between Gadobenate and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline QTc and electrolytes in patients with additional risk factors, and consider ECG monitoring after contrast administration. No routine interruption of sotalol is usually needed.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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