Drug interactions
Galantamine + Haloperidol
Severity: Minor
Galantamine and Haloperidol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Haloperidol is a CYP2D6 substrate and weak inhibitor, which could modestly raise galantamine exposure. The clinical effect is small and unlikely to matter in most patients. Pharmacodynamically, galantamine may also oppose antipsychotic effects and increase extrapyramidal symptoms, but this is not a kinetic issue.
What this interaction means in plain words
Galantamine and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6-mediated galantamine metabolism by haloperidol.
What to do
No dose change is normally needed; monitor for cholinergic effects such as nausea, bradycardia and for worsening of extrapyramidal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Galantamine and Haloperidol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Haloperidol?
MediHelp rates the interaction as minor. Galantamine and Haloperidol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Haloperidol is a CYP2D6 substrate and weak inhibitor, which could modestly raise galantamine exposure. The clinical effect is small and unlikely to matter in most patients. Pharmacodynamically, galantamine may also oppose antipsychotic effects and increase extrapyramidal symptoms, but this is not a kinetic issue.
How serious is the interaction between Galantamine and Haloperidol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor for cholinergic effects such as nausea, bradycardia and for worsening of extrapyramidal symptoms.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
