Drug interactions
Galantamine + Perphenazine
Severity: Minor
Galantamine and Perphenazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine inhibits CYP2D6 and may modestly raise galantamine concentrations, increasing cholinergic effects such as nausea, bradycardia and vomiting. Galantamine's cholinergic action may also oppose antipsychotic effects, though this is not a pharmacokinetic issue.
What this interaction means in plain words
Galantamine and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Galantamine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Perphenazine inhibition of CYP2D6-mediated galantamine metabolism.
What to do
Monitor heart rate and gastrointestinal tolerability when starting or adjusting perphenazine. Reduce the galantamine dose if cholinergic adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Perphenazine?
MediHelp rates the interaction as minor. Galantamine and Perphenazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine inhibits CYP2D6 and may modestly raise galantamine concentrations, increasing cholinergic effects such as nausea, bradycardia and vomiting. Galantamine's cholinergic action may also oppose antipsychotic effects, though this is not a pharmacokinetic issue.
How serious is the interaction between Galantamine and Perphenazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerability when starting or adjusting perphenazine. Reduce the galantamine dose if cholinergic adverse effects emerge.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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