Drug interactions
Galantamine + Solifenacin
Severity: Moderate
Galantamine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Galantamine increases cholinergic activity while solifenacin blocks muscarinic receptors, so the two drugs oppose one another. This may reduce the benefit of either drug and complicates treatment of cognitive symptoms and bladder symptoms.
What this interaction means in plain words
Galantamine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Solifenacin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between cholinesterase inhibition and muscarinic receptor blockade.
What to do
Avoid the combination where possible in dementia patients; consider a bladder agent with less central anticholinergic effect, such as a beta-3 agonist. Monitor cognition and urinary symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Solifenacin?
MediHelp rates the interaction as moderate. Galantamine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Galantamine increases cholinergic activity while solifenacin blocks muscarinic receptors, so the two drugs oppose one another. This may reduce the benefit of either drug and complicates treatment of cognitive symptoms and bladder symptoms.
How serious is the interaction between Galantamine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible in dementia patients; consider a bladder agent with less central anticholinergic effect, such as a beta-3 agonist. Monitor cognition and urinary symptoms.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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