Drug interactions
Galantamine + Voriconazole
Severity: Moderate
Galantamine and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase galantamine exposure, which could enhance cholinergic effects such as nausea, vomiting and bradycardia.
What this interaction means in plain words
Galantamine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Galantamine belongs to Central Nervous System; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4 (and CYP2D6 contribution) metabolism of galantamine by voriconazole.
What to do
Monitor heart rate and gastrointestinal tolerance, and consider reducing the galantamine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Galantamine
- Galantamine + Memantine-donepezil Major
- Galantamine + Physostigmine Major
- Galantamine + Ponesimod Major
- Galantamine + Rivastigmine Major
- Amifampridine + Galantamine Moderate
- Amiodarone + Galantamine Moderate
Frequently asked questions
Can I take Galantamine with Voriconazole?
MediHelp rates the interaction as moderate. Galantamine and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase galantamine exposure, which could enhance cholinergic effects such as nausea, vomiting and bradycardia.
How serious is the interaction between Galantamine and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and gastrointestinal tolerance, and consider reducing the galantamine dose if adverse effects appear.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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