Drug interactions
Ganaxolone + Hydroxyzine
Severity: Moderate
Ganaxolone and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone causes somnolence and sedation, and hydroxyzine is a sedating antihistamine. Together they may increase drowsiness and impair alertness and coordination.
What this interaction means in plain words
Ganaxolone and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Hydroxyzine belongs to Respiratory.
Why it happens
Additive CNS depression via GABA-A modulation (ganaxolone) and H1 antagonism (hydroxyzine).
What to do
Monitor for excessive sedation and consider reducing the dose of one agent if drowsiness is problematic. Advise caregivers and patients to avoid hazardous activities until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ganaxolone and Hydroxyzine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Hydroxyzine?
MediHelp rates the interaction as moderate. Ganaxolone and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone causes somnolence and sedation, and hydroxyzine is a sedating antihistamine. Together they may increase drowsiness and impair alertness and coordination.
How serious is the interaction between Ganaxolone and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider reducing the dose of one agent if drowsiness is problematic. Advise caregivers and patients to avoid hazardous activities until the response is known.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
