Drug interactions
Ganaxolone + Meperidine
Severity: Moderate
Ganaxolone and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone causes somnolence and sedation, and use with opioids can intensify CNS depression. Impaired alertness and respiratory depression may occur.
What this interaction means in plain words
Ganaxolone and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Meperidine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid receptor agonism and positive GABA-A modulation by ganaxolone.
What to do
Monitor for excessive sedation and respiratory depression, and reduce the dose of one or both agents if it occurs. Advise patients to avoid driving and other hazardous activity until effects are known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Meperidine?
MediHelp rates the interaction as moderate. Ganaxolone and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone causes somnolence and sedation, and use with opioids can intensify CNS depression. Impaired alertness and respiratory depression may occur.
How serious is the interaction between Ganaxolone and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and respiratory depression, and reduce the dose of one or both agents if it occurs. Advise patients to avoid driving and other hazardous activity until effects are known.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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