Drug interactions
Ganaxolone + Midazolam
Severity: Moderate
Ganaxolone and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid with sedative properties, so combining it with midazolam increases somnolence and CNS depression. This raises the risk of falls, impaired alertness and respiratory depression.
What this interaction means in plain words
Ganaxolone and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Midazolam belongs to Central Nervous System.
Why it happens
Additive positive allosteric modulation of GABA-A receptors.
What to do
Monitor sedation and respiratory status, and reduce the dose of one or both agents if excessive drowsiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Midazolam?
MediHelp rates the interaction as moderate. Ganaxolone and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid with sedative properties, so combining it with midazolam increases somnolence and CNS depression. This raises the risk of falls, impaired alertness and respiratory depression.
How serious is the interaction between Ganaxolone and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and reduce the dose of one or both agents if excessive drowsiness develops.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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