Drug interactions
Ganaxolone + Perphenazine
Severity: Moderate
Ganaxolone and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone causes somnolence and sedation, and perphenazine adds to CNS depression, so psychomotor impairment may increase.
What this interaction means in plain words
Ganaxolone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganaxolone belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A modulation and antipsychotic sedation.
What to do
Monitor for excessive sedation and adjust doses if needed. Advise caution with driving and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Ganaxolone with Perphenazine?
MediHelp rates the interaction as moderate. Ganaxolone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone causes somnolence and sedation, and perphenazine adds to CNS depression, so psychomotor impairment may increase.
How serious is the interaction between Ganaxolone and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and adjust doses if needed. Advise caution with driving and other CNS depressants.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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