Drug interactions
Ganciclovir + Hydrochlorothiazide-irbesartan
Severity: Minor
Ganciclovir and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are renally cleared, and hydrochlorothiazide-related volume depletion or reduced tubular secretion may raise ganciclovir exposure, increasing hematologic and renal toxicity risk.
What this interaction means in plain words
Ganciclovir and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ganciclovir belongs to Anti Virals; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular secretion and reduced renal clearance from volume depletion.
What to do
Monitor renal function and blood counts, adjusting ganciclovir dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Ganciclovir and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are renally cleared, and hydrochlorothiazide-related volume depletion or reduced tubular secretion may raise ganciclovir exposure, increasing hematologic and renal toxicity risk.
How serious is the interaction between Ganciclovir and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, adjusting ganciclovir dose to creatinine clearance.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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