Drug interactions
Ganciclovir + Pretomanid
Severity: Minor
Ganciclovir and Pretomanid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OAT3 in vitro, and ganciclovir is renally secreted partly by organic anion transporters. Ganciclovir exposure could increase, raising the risk of hematologic and other toxicity. Clinical data are lacking.
What this interaction means in plain words
Ganciclovir and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ganciclovir belongs to Anti Virals; Pretomanid belongs to Anti Bacterial.
Why it happens
Inhibition of OAT3-mediated renal secretion may reduce ganciclovir clearance.
What to do
Monitor blood counts and renal function during co-therapy. Consider ganciclovir dose reduction if cytopenias or toxicity develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ganciclovir
Other interactions of Pretomanid
Frequently asked questions
Can I take Ganciclovir with Pretomanid?
MediHelp rates the interaction as minor. Ganciclovir and Pretomanid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pretomanid inhibits OAT3 in vitro, and ganciclovir is renally secreted partly by organic anion transporters. Ganciclovir exposure could increase, raising the risk of hematologic and other toxicity. Clinical data are lacking.
How serious is the interaction between Ganciclovir and Pretomanid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function during co-therapy. Consider ganciclovir dose reduction if cytopenias or toxicity develop.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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