Drug interactions
Ganciclovir + Vadadustat
Severity: Moderate
Ganciclovir and Vadadustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vadadustat inhibits OAT3, a transporter involved in the renal secretion of ganciclovir. Ganciclovir exposure may therefore rise, increasing the risk of hematologic and other dose-related toxicity.
What this interaction means in plain words
Ganciclovir and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganciclovir belongs to Anti Virals; Vadadustat belongs to Endocrine.
Why it happens
Inhibition of OAT3-mediated renal tubular secretion of ganciclovir.
What to do
Monitor blood counts and renal function, and reduce the ganciclovir dose if toxicity appears or as indicated by labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ganciclovir
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Ganciclovir with Vadadustat?
MediHelp rates the interaction as moderate. Ganciclovir and Vadadustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vadadustat inhibits OAT3, a transporter involved in the renal secretion of ganciclovir. Ganciclovir exposure may therefore rise, increasing the risk of hematologic and other dose-related toxicity.
How serious is the interaction between Ganciclovir and Vadadustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function, and reduce the ganciclovir dose if toxicity appears or as indicated by labeling.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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