Drug interactions
Gefitinib + Mifepristone
Severity: Moderate
Gefitinib and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4, which is the main pathway for gefitinib metabolism. Gefitinib exposure may rise, increasing diarrhea, rash and hepatotoxicity.
What this interaction means in plain words
Gefitinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of gefitinib.
What to do
Monitor for gefitinib adverse effects including diarrhea, skin reactions and liver enzyme elevation. Interrupt or reduce therapy if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Mifepristone?
MediHelp rates the interaction as moderate. Gefitinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4, which is the main pathway for gefitinib metabolism. Gefitinib exposure may rise, increasing diarrhea, rash and hepatotoxicity.
How serious is the interaction between Gefitinib and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gefitinib adverse effects including diarrhea, skin reactions and liver enzyme elevation. Interrupt or reduce therapy if toxicity develops.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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