Drug interactions
Gefitinib + Nicardipine
Severity: Minor
Gefitinib and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gefitinib is metabolized mainly by CYP3A4, and nicardipine may raise its levels modestly. This could increase adverse effects such as diarrhea, rash and liver enzyme elevation.
What this interaction means in plain words
Gefitinib and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Gefitinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 metabolism of gefitinib by nicardipine.
What to do
Monitor for diarrhea, skin toxicity and liver enzyme changes, and manage gefitinib toxicity per usual practice.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Nicardipine?
MediHelp rates the interaction as minor. Gefitinib and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Gefitinib is metabolized mainly by CYP3A4, and nicardipine may raise its levels modestly. This could increase adverse effects such as diarrhea, rash and liver enzyme elevation.
How serious is the interaction between Gefitinib and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diarrhea, skin toxicity and liver enzyme changes, and manage gefitinib toxicity per usual practice.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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