Drug interactions
Gefitinib + Nizatidine
Severity: Moderate
Gefitinib and Nizatidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gefitinib absorption depends on gastric acidity, and drugs that sustain a raised gastric pH can lower its exposure. Reduced exposure may compromise tumor control.
What this interaction means in plain words
Gefitinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Nizatidine belongs to Gastrointestinal Tract.
Why it happens
Elevated gastric pH reduces the solubility and absorption of gefitinib.
What to do
Take gefitinib at least 12 hours before or 6 hours after the H2 blocker. Monitor for loss of efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nizatidine
- Atazanavir + Nizatidine Major
- Dasatinib + Nizatidine Major
- Erlotinib + Nizatidine Major
- Itraconazole + Nizatidine Major
- Ketoconazole + Nizatidine Major
- Nizatidine + Pazopanib Major
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Nizatidine?
MediHelp rates the interaction as moderate. Gefitinib and Nizatidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gefitinib absorption depends on gastric acidity, and drugs that sustain a raised gastric pH can lower its exposure. Reduced exposure may compromise tumor control.
How serious is the interaction between Gefitinib and Nizatidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take gefitinib at least 12 hours before or 6 hours after the H2 blocker. Monitor for loss of efficacy.
What other medicines interact with Nizatidine?
MediHelp also lists interactions of Nizatidine with, for example, Atazanavir, Dasatinib, Erlotinib. The full list is on the Nizatidine page.
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