Drug interactions
Gefitinib + Warfarin
Severity: Moderate
Gefitinib and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elevated INR and bleeding have been reported in patients taking warfarin with gefitinib. Labeling advises periodic INR monitoring.
What this interaction means in plain words
Gefitinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gefitinib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Mechanism is not established.
What to do
Monitor INR regularly during gefitinib therapy and reduce warfarin dose if INR rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Gefitinib
Frequently asked questions
Can I take Gefitinib with Warfarin?
MediHelp rates the interaction as moderate. Gefitinib and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elevated INR and bleeding have been reported in patients taking warfarin with gefitinib. Labeling advises periodic INR monitoring.
How serious is the interaction between Gefitinib and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR regularly during gefitinib therapy and reduce warfarin dose if INR rises.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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