Drug interactions
Gemcitabine + Hydroxyurea
Severity: Moderate
Gemcitabine and Hydroxyurea: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress bone marrow function, so combined use can worsen neutropenia and thrombocytopenia. Infection and bleeding risks rise accordingly.
What this interaction means in plain words
Gemcitabine and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemcitabine belongs to Oncology; Hydroxyurea belongs to Miscellaneous.
Why it happens
Additive myelosuppression through inhibition of DNA synthesis by two different mechanisms.
What to do
Monitor complete blood counts regularly and adjust the dose of one or both drugs based on cytopenias. Give supportive care as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Gemcitabine with Hydroxyurea?
MediHelp rates the interaction as moderate. Gemcitabine and Hydroxyurea can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress bone marrow function, so combined use can worsen neutropenia and thrombocytopenia. Infection and bleeding risks rise accordingly.
How serious is the interaction between Gemcitabine and Hydroxyurea?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and adjust the dose of one or both drugs based on cytopenias. Give supportive care as needed.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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