Drug interactions
Gemcitabine + Trastuzumab
Severity: Moderate
Gemcitabine and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab has been associated with more neutropenia and febrile neutropenia when added to myelosuppressive chemotherapy. Gemcitabine also suppresses the marrow, so infection risk may increase.
What this interaction means in plain words
Gemcitabine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemcitabine belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression; the trastuzumab contribution is not fully understood.
What to do
Monitor blood counts and assess fever promptly. Adjust the gemcitabine dose according to hematologic toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemcitabine
Other interactions of Trastuzumab
Frequently asked questions
Can I take Gemcitabine with Trastuzumab?
MediHelp rates the interaction as moderate. Gemcitabine and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab has been associated with more neutropenia and febrile neutropenia when added to myelosuppressive chemotherapy. Gemcitabine also suppresses the marrow, so infection risk may increase.
How serious is the interaction between Gemcitabine and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and assess fever promptly. Adjust the gemcitabine dose according to hematologic toxicity.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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